The effects of KEM CON ONG and KEM TRI BONG creams on doxorubicin-induced skin ulcer in rats
نویسندگان
چکیده
The present study evaluated the effects of topical administration KEM CON ONG and TRI BONG creams on doxorubicin-induced skin ulcer, their systemic toxicity in ulcerated rats. lesions were induced by a single intradermal injection 0.2ml doxorubicin 1 mg/0.5ml dorsal region. areas covered topically with dimethyl sulfoxide, ONG, or twice day for 28 days. results indicated that significantly reduced ulcer size, increased hydroxyproline content animals’ tissues, improved histopathological structure tissues. No significant difference healing effect was observed between BONG-treated Besides, our demonstrated caused no change general status, hematological parameters, renal hepatic functions. Additionally, they did not alter histology liver kidney animals. In conclusion, application exerted cause rat model.
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ژورنال
عنوان ژورنال: T?p chí Nghiên c?u Y h?c
سال: 2023
ISSN: ['2354-080X']
DOI: https://doi.org/10.52852/tcncyh.v166i5e12.1523